Article

The Holliday junction resolvase GEN1 preserves genome integrity and self-renewal in mouse embryonic stem cells

2026-07-23

Abstract excerpt

<h4>Summary</h4> The maintenance of pluripotent stem cells (PSCs) under rapid proliferation requires mechanisms that both suppress replication-driven genome instability and preserve self-renewal capacity. Here, we show that, in contrast to somatic cells where it mainly acts as a backup, the Holliday junction resolvase GEN1 is required in mouse embryonic stem cells (ESCs), where its depletion severely compromises...

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Literature Corpus work: 64660949-044a-5506-9d0e-3025b3b5c3e1
DOI: 10.64898/2026.07.23.740277

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