Article
Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2011
Hartford Suzanne A, Luo Yunhai, Southard Teresa L, Min Irene M, Lis John T, Schimenti John C
Abstract excerpt
Effective DNA replication is critical to the health and reproductive success of organisms. The six MCM2-7 proteins, which form the replicative helicase, are essential for high-fidelity replication of the genome. Many eukaryotes have a divergent paralog, MCM9, that was reported to be essential for loading MCM2-7 onto replication origins in the Xenopus oocyte extract system. To address the in vivo role of mammalian...
Topics
- Animals
- Carcinoma, Hepatocellular
- Cell Cycle
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- DNA Replication
- DNA-Binding Proteins
- Gametogenesis
- Gene Components
- Genomic Instability