Article

The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integrity

2021-02-16

Abstract excerpt

<h4>ABSTRACT</h4> Several studies have shown a role for Stag proteins in cell identity. Our understanding of how Stag proteins contribute to cell identity have largely been focused on its roles in chromosome topology as part of the cohesin complex and the impact on protein-coding gene expression. Furthermore, several Stag paralogs exist in mammalian cells with non-reciprocal chromosome structure and cohesion func...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56b39d28-0e81-5336-9fdf-cbe0be0c8f37
DOI: 10.1101/2021.02.14.429938

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integrityDOI 10.1101/2021.02.14.429938Read

STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasmSemantic proximity Read

STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cellsSemantic proximity Read

Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrumSemantic proximity Read

STAG2 cohesin is essential for heart morphogenesisSemantic proximity Read

Cohesin mutations in myeloid malignancies made simple.Semantic proximity Read

STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cellsSemantic proximity Read

Co-Essentiality Analysis Identifies PRR12 as a Regulator of Cohesin and Genome IntegritySemantic proximity Read

Staufen2 modulates the temporal dynamics of human neurogenesis <i>in vitro</i>Semantic proximity Read

AT-hook-dependent DNA loop extrusion by STAG1 drives 3D genome foldingSemantic proximity Read

STAG3 is a strong candidate gene for male infertilitySemantic proximity Read

Mutations in STAG2 cause an X-linked cohesinopathy associated with undergrowth, developmental delay, and dysmorphia: Expanding the phenotype in males.Semantic proximity Read

STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia.Semantic proximity Read