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Article

Genome Maintenance in Mammalian Stem Cells.

Annual review of genetics - 30 Nov 2022

Schimenti John C, Huang Rui, Li Liangdao, James Ryan

Abstract excerpt

Various stem cells in the body are tasked with maintaining tissue homeostasis throughout the life of an organism and thus must be resilient to intrinsic and extrinsic challenges such as infection and injury. Crucial to these challenges is genome maintenance because a high mutational load and persistent DNA lesions impact the production of essential gene products at proper levels and compromise optimal stem cell...

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PMID: 35977408
DOI: 10.1146/annurev-genet-072920-022154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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