Article

Extruding transcription elongation loops observed in high-resolution single-cell 3D genomes

2023-02-19

Abstract excerpt

Inside human nuclei, genes are transcribed within a highly packed genome, whose organization is facilitated by cohesin-mediated loop extrusion. However, whether cohesin-mediated loop extrusion participates in transcription is unknown. Here we report that the cohesin-mediated loop extrusion participates in transcription by forming a topoisomerases-regulated transcription elongation loop (TEL), in which cohesin is s...

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Literature Corpus work: 3e0c8bd6-7786-5033-93cc-ba86442268d1
DOI: 10.1101/2023.02.18.529096

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