Article
CTCF physically links cohesin to chromatin.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2008
Rubio Eric D, Reiss David J, Welcsh Piri L, Disteche Christine M, Filippova Galina N, Baliga Nitin S, Aebersold Ruedi, Ranish Jeffrey A, Krumm Anton
Abstract excerpt
Cohesin is required to prevent premature dissociation of sister chromatids after DNA replication. Although its role in chromatid cohesion is well established, the functional significance of cohesin's association with interphase chromatin is not clear. Using a quantitative proteomics approach, we show that the STAG1 (Scc3/SA1) subunit of cohesin interacts with the CCTC-binding factor CTCF bound to the c-myc...
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