Article

NIPBL and WAPL balance cohesin activity to regulate chromatin folding and gene expression

2022-04-19

Abstract excerpt

The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. We investigated the roles of NIPBL and WAPL, two regulators of cohesin activity, in chromatin folding and transcription in human cells. Consistent with their opposing roles in cohesin regulation, depletion of these factors showed opposite effects on levels of chromatin-bound cohesin and spatial insulation of neighborin...

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Literature Corpus work: d6646993-1cfc-55c5-ab6c-75832f91bad3
DOI: 10.1101/2022.04.19.488785

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