Article

Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function

2017-07-31

Abstract excerpt

The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B – Mau2 protein complex loads cohesin onto chromosomes and the Pds5 - Wapl complex removes cohesin. Pds5 is also essential for sister chromatid cohesion, indicating that it has functio...

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Literature Corpus work: be887b72-2e95-5ca2-ac7f-899306f8d0ed
DOI: 10.1101/170829

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