Article

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

2017-07-20

Abstract excerpt

In addition to mediating sister chromatid cohesion, cohesin plays a central role in DNA looping and segmentation of the genome into contact domains (TADs). Two variant cohesin complexes that contain either STAG/SA1 or SA2 are present in all cell types. Here we addressed their specific contribution to genome architecture in non-transformed human cells. We found that cohesin-SA1 drives stacking of cohesin rings at C...

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Literature Corpus work: 7546bec7-1d72-5b71-96cb-0da4a818a5a9
DOI: 10.1101/166264

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