Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leveraging allelic imbalance in accessible chromatin to prioritize putative causal variants.

Trends in genetics : TIG - 1 May 2026

Morilla Lordjie Marr O, Amoaning Regina E, Luo Shumeng, Moharam Riham G, Huang Chien-Ling, Yip Shea Ping

Abstract excerpt

Genome-wide association studies (GWASs) have uncovered many SNPs associated with complex diseases, but identifying the causal genetic variants remains very difficult. This review focuses on allele-specific chromatin accessibility (CA) variants (ASCAVs)-which are SNPs that influence CA, binding of transcription factors, and gene expression-by integrating allelic imbalance analysis with assay for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Allelic Imbalance
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation Sequencing

Share to Gene Expression Regulation

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 41720716
DOI: 10.1016/j.tig.2025.12.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leveraging allelic imbalance in accessible chromatin to prioritize putative causal variants.PMID 41720716Read ↗

Multi-tissue analyses of allele-specific chromatin accessibility nominate likely functional variants for type 2 diabetesSemantic proximity Read ↗

Genetic determinants of chromatin accessibility in T cell activation across humansSemantic proximity Read ↗

ANANASTRA: annotation and enrichment analysis of allele-specific transcription factor binding at SNPs.Semantic proximity Read ↗

Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanismsSemantic proximity Read ↗

Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms.Semantic proximity Read ↗

Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms.Semantic proximity Read ↗

Interrogation of allelic chromatin states in human cells by high-density ChIP-genotyping.Semantic proximity Read ↗

Genetic determinants of co-accessible chromatin regions in activated T cells across humans.Semantic proximity Read ↗

A uniform survey of allele-specific binding and expression over 1000-Genomes-Project individuals.Semantic proximity Read ↗

Allelic imbalance assays to quantify allele-specific gene expression and transcription factor binding.Semantic proximity Read ↗

Landscape of allele-specific transcription factor binding in the human genomeSemantic proximity Read ↗

Landscape of allele-specific transcription factor binding in the human genome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.