Article
Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanisms.
Genome biology - 30 Mar 2025
Wenz Brandon M, He Yuan, Chen Nae-Chyun, Pickrell Joseph K, Li Jeremiah H, Dudek Max F, Li Taibo, Keener Rebecca, Voight Benjamin F, Brown Christopher D, Battle Alexis
Abstract excerpt
BACKGROUND: Understanding the genetic causes underlying variability in chromatin accessibility can shed light on the molecular mechanisms through which genetic variants may affect complex traits. Thousands of ATAC-seq samples have been collected that hold information about chromatin accessibility across diverse cell types and contexts, but most of these are not paired with genetic information and come from...
Read the complete abstract on PubMedTopics
- Quantitative Trait Loci
- Humans
- Chromatin
- Genotype
- Gene Expression Regulation