Article

Lung-mimicking 3-Dimensional hydrogel culture system recapitulates key tuberculosis phenotypes and demonstrates pyrazinamide efficacy

2023-01-25

Abstract excerpt

Faithful mimics of tuberculosis (TB) infection are needed to provide mechanistic insights into the complex host-pathogen interactions and accelerate drug discovery. Current in vitro models only allow short investigation durations, present divergent transcriptional signatures to human infections, and are unreliable drug discovery platforms. We developed a 3D collagen culture system mimicking the lung microenvironm...

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Identifiers and source

Literature Corpus work: 63e07727-ff70-5d62-aaaa-823fb81a0b77
DOI: 10.1101/2023.01.24.525291

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