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Article

Comparative transcriptomic profiling of pyrazinamide resistance in Mycobacterium tuberculosis.

Journal of applied microbiology - 5 Mar 2026

Rajendran Ananthi, Refaya Ahmed Kabir, Palaniyandi Kannan

Abstract excerpt

AIMS: Pyrazinamide (PZA) resistance in Mycobacterium tuberculosis challenges tuberculosis management, primarily through pncA mutations, while broader transcriptional adaptations remain unclear. This study aimed to characterize the transcriptomic adaptations associated with PZA resistance using a PZA-resistant clinical strain carrying a 10-nucleotide deletion in pncA (positions 118-127) that abolishes PZA...

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Identifiers

PMID: 41784510
DOI: 10.1093/jambio/lxag064

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