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Article

Doxycycline host-directed therapy in human pulmonary tuberculosis

15 Jun 2021

Abstract excerpt

BACKGROUNDMatrix metalloproteinases (MMPs) are key regulators of tissue destruction in tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II double-blind, randomized, controlled trial investigating doxycycline, a licensed broad-spectrum MMP inhibitor, in patients with pulmonary TB.METHODSThirty patients with pulmonary TB were enrolled within 7 days of initiating anti-TB treatment...

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PMID: 34128838
DOI: 10.1172/jci141895

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