Back to search

Article

A bovine pulmosphere model and multiomics analyses identify a signature of early host response to <i>Mycobacterium tuberculosis</i> infection

2023-12-08

Abstract excerpt

Interactions between the tubercle bacilli and lung cells during the early stages of tuberculosis (TB) are crucial for disease outcomes. Conventional 2D cell culture inadequately replicates the multicellular complexity of lungs. We introduce a 3D pulmosphere model for Mycobacterium tuberculosis infection in bovine systems, demonstrating through comprehensive transcriptome and proteome analyses that these 3D struct...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bea36117-b83d-5b33-a2ca-315637b23136
DOI
10.1101/2023.12.07.570553
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A bovine pulmosphere model and multiomics analyses identify a signature of early host response to <i>Mycobacterium tuberculosis</i> infectionDOI 10.1101/2023.12.07.570553
A bovine pulmosphere model and multiomics reveal early host response signature in tuberculosisSemantic proximity
Transcriptomic Insights into Mycobacterium orygis Infection-associated Pulmonary Granulomas Reveal Multicellular Immune Networks and Tuberculosis Biomarkers in Cattle.Semantic proximity
Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogensSemantic proximity
Comparative ‘omics analyses differentiate <i>Mycobacterium tuberculosis</i> and <i>Mycobacterium bovis</i> and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilliSemantic proximity
Mycobacterial infection of precision cut lung slices reveals that the type 1 interferon pathway is locally induced by Mycobacterium bovis but not M. tuberculosis in different cattle breedsSemantic proximity
Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional modelSemantic proximity
Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis GranulomasSemantic proximity
Mycobacterium tuberculosis: An Adaptable Pathogen Associated With Multiple Human DiseasesSemantic proximity
Comparative 'omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilliSemantic proximity
Soluble immune mediators orchestrate protective <i>in vitro</i> granulomatous responses across <i>Mycobacterium tuberculosis</i> complex lineagesSemantic proximity
Comparative multi-omics of the macrophage response to infection with <i>Mycobacterium tuberculosis</i> complex bacteria reveals pathogen-driven epigenomic reprogrammingSemantic proximity
A single-cell transcriptomic atlas of the lungs of patients with pulmonary tuberculosisSemantic proximity
Select a neighboring publication to make it the new centre.