Article

Deciphering the transcriptomic landscape of pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>

2025-10-14

Abstract excerpt

Pyrazinamide resistance in Mycobacterium tuberculosis poses a major challenge to tuberculosis management and is primarily linked to pncA mutations, while the broader transcriptional adaptations underlying this resistance remain unclear. In this study, we performed a comparative analysis of the transcriptomic response of a mutant clinical strain and the drug-susceptible laboratory strain H37Rv under PZA exposure...

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Literature Corpus work: 90c9f87e-5d9b-5549-a51e-e16c3eb26ddf
DOI: 10.1101/2025.10.13.681998

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