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Article

3D Hydrogel Culture System Recapitulates Key Tuberculosis Phenotypes and Demonstrates Pyrazinamide Efficacy.

Advanced healthcare materials - 1 Feb 2025

Gupta Vishal K, Vaishnavi Vijaya V, Arrieta-Ortiz Mario L, P S Abhirami, K M Jyothsna, Jeyasankar Sharumathi, Raghunathan Varun, Baliga Nitin S, Agarwal Rachit

Abstract excerpt

The mortality caused by tuberculosis (TB) infections is a global concern, and there is a need to improve understanding of the disease. Current in vitro infection models to study the disease have limitations such as short investigation durations and divergent transcriptional signatures. This study aims to overcome these limitations by developing a 3D collagen culture system that mimics the biomechanical and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38655817
DOI: 10.1002/adhm.202304299
PMCID: PMC7616495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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