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A bovine pulmosphere model and multiomics reveal early host response signature in tuberculosis

4 Apr 2025

Abstract excerpt

Early interactions between tubercle bacilli and lung cells are critical in tuberculosis (TB) pathogenesis. Conventional two-dimensional cell cultures fail to replicate the multicellular complexity of lungs. We introduce a three-dimensional pulmosphere model for Mycobacterium tuberculosis infection in bovine systems, demonstrating through comprehensive transcriptome and proteome analyses that these multicellular...

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PMID: 40186000
DOI: 10.1038/s42003-025-07883-6

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