Article

Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies

2025-11-11

Abstract excerpt

<h4>SUMMARY</h4> Tuberculosis (TB) remains a major global health challenge that requires new therapeutic strategies to improve drug efficacy, shorten treatment duration, prevent drug resistance, and limit Mycobacterium tuberculosis (Mtb) persistence. Here, we established complementary in vitro human lung models integrating alveolar macrophage-like (AML) cells and airway air-liquid interface (ALI) cultures to ev...

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Literature Corpus work: f1ccc00d-3776-5fbf-beec-41cd129eb420
DOI: 10.1101/2025.11.10.685269

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