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Genetic Modification in Human Pluripotent Stem Cells by Homologous Recombination and CRISPR/Cas9 System.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Xue Haipeng, Wu Jianbo, Li Shenglan, Rao Mahendra S, Liu Ying

Abstract excerpt

Genetic modification is an indispensable tool to study gene function in normal development and disease. The recent breakthrough of creating human induced pluripotent stem cells (iPSCs) by defined factors (Takahashi et al., Cell 131:861-872, 2007) provides a renewable source of patient autologous cells that not only retain identical genetic information but also give rise to many cell types of the body including...

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PMID: 24615461
DOI: 10.1007/7651_2014_73

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