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CRISPR‐Cas9‐Based Genome Editing of Human Induced Pluripotent Stem Cells

1 Feb 2018

Abstract excerpt

Human induced pluripotent stem cells (hiPSCs) are the ideal cell source for autologous cell replacement. However, for patients with Mendelian diseases, genetic correction of the original disease-causing mutation is likely required prior to cellular differentiation and transplantation. The emergence of the CRISPR-Cas9 system has revolutionized the field of genome editing. By introducing inexpensive reagents that...

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PMID: 29512106
DOI: 10.1002/cpsc.46

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