Article

Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures

2023-06-28

Abstract excerpt

<h4>ABSTRACT</h4> α-Synuclein (α-syn) forms amyloid fibrils that are critical in the progression of Parkinson’s disease (PD) and serves as the pathological hallmark of PD. Different posttranslational modifications (PTMs) have been identified at multiple sites of α-syn, influencing its conformation, aggregation and function. Here, we investigate how disease-related phosphorylation and O-GlcNAcylation at the same α...

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Literature Corpus work: 8949ca6e-d7b0-5705-8d48-9b5b4af0141d
DOI: 10.1101/2023.06.27.546682

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