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Article

Effects of Mutations and Post-Translational Modifications on α-Synuclein In Vitro Aggregation.

Journal of molecular biology - 15 Dec 2022

Pancoe Samantha X, Wang Yanxin J, Shimogawa Marie, Perez Ryann M, Giannakoulias Sam, Petersson E James

Abstract excerpt

Fibrillar aggregates of the α-synuclein (αS) protein are the hallmark of Parkinson's Disease and related neurodegenerative disorders. Characterization of the effects of mutations and post-translational modifications (PTMs) on the αS aggregation rate can provide insight into the mechanism of fibril formation, which remains elusive in spite of intense study. A comprehensive collection (375 examples) of mutant and...

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Identifiers

PMID: 36270580
DOI: 10.1016/j.jmb.2022.167859
PMCID: PMC9922159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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