Article

Genetic Code Expansion and Enzymatic Modifications as Accessible Methods for Studying Site-Specific Post-Translational Modifications of Alpha-Synuclein and Tau

2025-05-17

Abstract excerpt

Alpha-synuclein (αS) and tau play important roles in the pathology of Parkinson’s Disease and Alzheimer’s Disease, respectively, as well as numerous other neurodegenerative diseases. Both proteins are classified as intrinsically disordered proteins (IDPs), as they have no stable structure that underlies their function in healthy tissue, and both proteins are prone to aggregation in disease states. There is substan...

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Literature Corpus work: 01ca24f2-8f9f-5329-9859-2d922a2084b6
DOI: 10.1101/2025.05.16.654576

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