Article

The Myc-Like Mlx Network Impacts Aging and Metabolism

2023-11-27

Abstract excerpt

The “Mlx” and “Myc” Networks share many common gene targets. Just as Myc’s activity depends upon its heterodimerization with Max, the Mlx Network requires that the Max-like factor Mlx associate with the Myc-like factors MondoA or ChREBP. We show here that body-wide Mlx inactivation, like that of Myc, accelerates numerous aging-related phenotypes pertaining to body habitus and metabolism. The deregulation of nume...

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Identifiers and source

Literature Corpus work: 62edf053-1385-52f7-81ce-9661459ad504
DOI: 10.1101/2023.11.26.568749

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