Article
DREAM repressive activity links somatic mutation, lifespan and disease.
Nature aging - 1 Jun 2026
Koch Zane, Nandi Shuvro P, Licon Kate, Bujarrabal-Dueso Arturo, Meyer David H, Saeed Safa, Perampalam Pirunthan, Dick Frederick A, Schumacher Björn, Alexandrov Ludmil B, Ideker Trey
Abstract excerpt
The DREAM complex has emerged as a central repressor of DNA repair, raising questions as to whether such repression exerts long-term effects on human health. Here we establish that DREAM-associated activity significantly impacts lifetime somatic mutation burden, and that such effects are linked to altered lifespan and age-related disease pathology. First, joint profiling of DREAM-associated activity (quantified...
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