Article

MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis

2020-12-23

Abstract excerpt

Male germ cell production is a metabolically-driven and apoptosis-prone process. Here we show that the glucose-sensing transcription factor MLX, and its binding partner MondoA, are both required for male fertility in the mouse, as well as survival of human tumor cells derived from the male germ line. Loss of Mlx results in altered metabolism as well as activation of multiple stress pathways and germ cell apoptosi...

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Identifiers and source

Literature Corpus work: 8be8f601-5020-542c-80d2-ed6da68df7fe
DOI: 10.1101/2020.12.23.424063

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