Article

Metformin extends the lifespan of iMSUD mice by rescuing physiologic dysfunction and modulating mechanisms of mTORC1 activation

2020-07-08

Abstract excerpt

<title>Abstract</title> <p><bold>Background- </bold>Dysregulation of branched chain amino acid (BCAA) catabolism caused by mutations in the metabolizing enzyme-branched chain alpha-keto acid dehydrogenase (BCKDH) leads to the fatal newborn disorder Maple Syrup Urine Disease (MSUD) and is linked to chronic diseases such as type 2 diabetes. <bold>Results- </bold>Here we show that a MSUD mouse model with severely re...

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Literature Corpus work: 7798d50f-90a4-594f-aec1-b5625bca22a6
DOI: 10.21203/rs.3.rs-39327/v1

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