Article

The DREAM complex links somatic mutation, lifespan, and disease

2025-09-18

Abstract excerpt

The DREAM complex has emerged as a central repressor of DNA repair, raising questions as to whether such repression exerts long-term effects on human health. Here we establish that DREAM activity significantly impacts lifetime somatic mutation burden, and that such effects are linked to altered lifespan and age-related disease pathology. First, joint profiling of DREAM activity and somatic mutations across a singl...

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Literature Corpus work: 22db39eb-082a-560e-b63e-29b936c43c92
DOI: 10.1101/2025.09.15.676396

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