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Article

Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

22 Mar 2016

Abstract excerpt

Germline removal provokes longevity in several species and shifts resources towards survival and repair. Several Caenorhabditis elegans transcription factors regulate longevity arising from germline removal; yet, how they work together is unknown. Here we identify a Myc-like HLH transcription factor network comprised of Mondo/Max-like complex (MML-1/MXL-2) to be required for longevity induced by germline removal,...

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PMID: 27001890
DOI: 10.1038/ncomms10944

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