Article

Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype

2025-06-30

Abstract excerpt

<title>Abstract</title> <p>Anxiety and depression are common in Parkinson's disease (PD), affecting quality of life. Aggregates of α-synuclein (α-Syn) are found in serotonergic (5-HT) raphe nuclei early in the disease, but their relationship to brain changes is unclear. We investigated synaptic plasticity, neuronal activity, and functional magnetic resonance imaging (fMRI)-based brain connectivity in a PD-like mo...

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Literature Corpus work: 62d71a79-2ed1-5542-ae37-37aef9aaff58
DOI: 10.21203/rs.3.rs-6179126/v1

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