Article

Early nigrostriatal synaptic dysfunction underlies prodromal non-motor symptoms preceding dopaminergic neurodegeneration in an MPTP mouse model of Parkinson’s disease

2026-04-20

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is characterized by progressive degeneration of nigrostriatal dopaminergic neurons; however, non-motor symptoms frequently emerge years before the onset of classical motor deficits. The biological mechanisms underlying these early manifestations remain poorly understood. Here, we investigated the temporal relationship between nigrostriatal degeneration, behaviou...

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Literature Corpus work: fc120a7e-3720-5d2e-934a-37af1a15a7c7
DOI: 10.21203/rs.3.rs-9331850/v1

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Early nigrostriatal synaptic dysfunction underlies prodromal non-motor symptoms preceding dopaminergic neurodegeneration in an MPTP mouse model of Parkinson’s diseaseDOI 10.21203/rs.3.rs-9331850/v1Read

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