Article

Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype

2025-04-24

Abstract excerpt

Anxiety and depression are common in Parkinson’s disease (PD), affecting quality of life. Aggregates of α-synuclein (α-Syn) are found in serotonergic (5-HT) raphe nuclei early in the disease, but their relationship to brain changes is unclear. We investigated synaptic plasticity, neuronal activity, and functional magnetic resonance imaging (fMRI)-based brain connectivity in a PD-like mouse model with depressive ph...

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Literature Corpus work: 470438cc-702d-52eb-a25f-6b30a135abb3
DOI: 10.1101/2025.04.24.650442

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