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Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson's disease patients with PINK1 and PARK2 mutations

2023-01-24

Abstract excerpt

<title>Abstract</title> <p>Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. Primary symptoms of PD arise with the loss of dopaminergic (DA) neurons in the Substantia Nigra Pars Compacta, but it affects the hippocampus and cortex also, usually in its later stage. Approximately 15% of PD cases familial with a genetic mutation. Two of the most associated genes with autosomal recessive...

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Literature Corpus work
a842de24-9616-5798-8562-dd04f964e092
DOI
10.21203/rs.3.rs-2456582/v1
Open publication

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Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson's disease patients with PINK1 and PARK2 mutationsDOI 10.21203/rs.3.rs-2456582/v1
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