Article

Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson’s disease patients

2022-01-02

Abstract excerpt

Several mutations that cause Parkinson’s disease (PD) have been identified over the past decade. These account for 15-25% of PD cases; the rest of the cases are considered sporadic. Currently, it is accepted that PD is not a single monolithic disease but rather a constellation of diseases with some common phenotypes. While rodent models exist for some of the PD-causing mutations, research on the sporadic forms of...

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Literature Corpus work: 9b9d8b7f-20e5-5d2d-a3b0-e4e0e47b0cf0
DOI: 10.1101/2021.12.31.474654

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