Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutations

Abstract excerpt

<title>Abstract</title> <p><italic>SYNGAP1</italic> is a critical gene for neuronal development, synaptic structure, and function. Although rare, the disruption of <italic>SYNGAP1</italic> directly causes a genetically identifiable neurodevelopmental disorder (NDD) called SYNGAP1-related intellectual disability. Without functional SynGAP1 protein, patients present with intellectual disability, motor impairments,...

Topics

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• Behavior, Animal
• Disease Models, Animal
• Electroencephalography
• Intellectual Disability
• Mice
• Neurons
• Phenotype
• ras GTPase-Activating Proteins

Identifiers and source

Literature Corpus work

3d0f5871-0a7a-5c05-9aa1-55ffe5d42c48

DOI

10.21203/rs.3.rs-3246655/v1