Article

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

2022-11-01

Abstract excerpt

Parkinson’s disease (PD) is a multisystemic disorder that manifests through motor and non-motor symptoms. Motor dysfunction is the most debilitating and it is caused by the degeneration of dopamine-producing neurons in the substantia nigra pars compacta (SNpc). Increasing evidence suggests that synapse dysfunction precedes neuronal loss by years. Still, early synaptic alterations in PD remain poorly understood. He...

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Literature Corpus work: 234c9ab6-62c1-5cf2-ba9b-869c81b32a25
DOI: 10.1101/2022.10.31.514622

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