Article

High-resolution TADs reveal DNA sequences underlying genome organization in flies

2017-03-08

Abstract excerpt

Eukaryotic chromatin is partitioned into domains called TADs that are broadly conserved between species and virtually identical among cell types within the same species. Previous studies in mammals have shown that the DNA binding protein CTCF and cohesin contribute to a fraction of TAD boundaries. Apart from this, the molecular mechanisms governing this partitioning remain poorly understood. Using our new software...

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Literature Corpus work: 40437696-9195-55a0-b489-cdf180519f4a
DOI: 10.1101/115063

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