Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.

Development (Cambridge, England) - 1 Oct 2011

Shi Qing, Li Shuang, Jia Jianhang, Jiang Jin

Abstract excerpt

Hedgehog (Hh) transduces signal by regulating the subcellular localization and conformational state of the GPCR-like protein Smoothened (Smo) but how Smo relays the signal to cytoplasmic signaling components remains poorly understood. Here, we show that Hh-induced Smo conformational change recruits Costal2 (Cos2)/Fused (Fu) and promotes Fu kinase domain dimerization. We find that induced dimerization through the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dimerization
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Resonance Energy Transfer

Share to Hedgehog Proteins

Share to Kinesins

Share to Receptors, G-Protein-Coupled

Share to RNA Interference

Share to Smoothened Receptor

Source

Open in PubMed Open full text

Identifiers

PMID: 21852395
DOI: 10.1242/dev.067959
PMCID: PMC3171222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.PMID 21852395Read ↗

Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.Semantic proximity Read ↗

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.Semantic proximity Read ↗

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Semantic proximity Read ↗

Hedgehog regulates smoothened activity by inducing a conformational switch.Semantic proximity Read ↗

Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling.Semantic proximity Read ↗

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.Semantic proximity Read ↗

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesisSemantic proximity Read ↗

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.Semantic proximity Read ↗

Regulation of Hedgehog Signal Transduction by Ubiquitination and DeubiquitinationSemantic proximity Read ↗

Extensive phosphorylation of Smoothened in Hedgehog pathway activation.Semantic proximity Read ↗

The Hedgehog Signal Transduction NetworkSemantic proximity Read ↗

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.