Article

Dihydrolipoamide dehydrogenase suppression induce human tau phosphorylation by increasing whole body glucose levels in a C . elegans model of Alzheimer’s Disease

2017-11-17

Abstract excerpt

The microtubule associated tau protein becomes hyperphosphorylated in Alzheimer’s disease (AD). While hyperphosphorylation promotes neurodegeneration, the cause and consequences of this abnormal modification are poorly understood. As impaired energy metabolism is an important hallmark of AD progression, we tested whether it could trigger phosphorylation of human tau protein in a transgenic C. elegans model of AD....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 61ea7e62-03a9-5845-af71-2da9bbe07f4b
DOI: 10.1101/220442

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dihydrolipoamide dehydrogenase suppression induce human tau phosphorylation by increasing whole body glucose levels in a C . elegans model of Alzheimer’s DiseaseDOI 10.1101/220442Read

Suppression of the dihydrolipoamide dehydrogenase gene ( dld-1 ) protects against the toxicity of human amyloid beta in C. elegans model of Alzheimer’s diseaseSemantic proximity Read

Tau Clearance Reverses Neuronal Dysfunction in Both Young and Aged C. elegansSemantic proximity Read

Glucose facilitates Aβ oligomerization and tau phosphorylation in C. elegans model of Alzheimer’s diseaseSemantic proximity Read

Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid betaSemantic proximity Read

Mimicking of tau hyperphosphorylation in GABAergic motoneurons of C. elegans induces severe peripheral and neuronal alterationsSemantic proximity Read

Tunable Tau Expression in C. elegans Neurons Reveals that Early-AD Tau Phosphorylation Selectively Impacts Behavior and Mitochondrial Quality ControlSemantic proximity Read

Human tau compromises neuronal structural integrity in C. elegans promoted by age, stress and phosphorylationSemantic proximity Read

Glucose availability impacts proteotoxic stress in Caenorhabditis elegansSemantic proximity Read

Alzheimer’s disease-relevant tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic modelSemantic proximity Read

Protein with tau-like repeats regulates neuronal integrity and lifespan inC. elegansSemantic proximity Read

Transgenic C. elegans as a model in Alzheimer's research.Semantic proximity Read

Glucose promotes neuron morphology abnormalities and egg-laying defects dependent of the serotonin signaling pathway in Caenorhabditis elegansSemantic proximity Read

Dihydrolipoamide dehydrogenase suppression induce human tau phosphorylation by increasing whole body glucose levels in a <i>C</i> . <i>elegans</i> model of Alzheimer’s Disease

Abstract excerpt

Topics

Identifiers and source

Related research