Article

Glucose facilitates Aβ oligomerization and tau phosphorylation in <i>C. elegans</i> model of Alzheimer’s disease

2017-12-03

Abstract excerpt

Formation of Aβ plaques from peptide oligomers and development of neurofibrillary tangles from hyperphosphorylated tau are hallmarks of Alzheimer’s disease (AD). These markers of AD severity are further associated with impaired glucose metabolism. However, the exact role of glucose metabolism on disease progression has not been elucidated. In this study, the effects of glucose on Aβ and tau-mediated toxicity are i...

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Literature Corpus work: 8ca96218-b3c9-5506-8380-cf69fc242252
DOI: 10.1101/228437

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