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Suppression of the dihydrolipoamide dehydrogenase gene ( <i>dld-1</i> ) protects against the toxicity of human amyloid beta in <i>C. elegans</i> model of Alzheimer’s disease

2017-12-04

Abstract excerpt

Declines in energy metabolism and associated mitochondrial enzymes are linked to the progression of Alzheimer’s disease (AD). Dihydrolipoamide dehydrogenase ( dld ) and two of its enzyme complexes namely, pyruvate dehydrogenase and α-ketoglutarate dehydrogenase are associated with AD and have a significant role in energy metabolism. Interestingly, dld gene variants are genetically linked to late-onset AD; and re...

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Literature Corpus work
2305f955-3003-5877-ba51-75d15ff60b5d
DOI
10.1101/228429
Open publication

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Suppression of the dihydrolipoamide dehydrogenase gene ( <i>dld-1</i> ) protects against the toxicity of human amyloid beta in <i>C. elegans</i> model of Alzheimer’s diseaseDOI 10.1101/228429
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