Back to search

Article

Mimicking of tau hyperphosphorylation in GABAergic motoneurons of <i>C. elegans</i> induces severe peripheral and neuronal alterations

2023-07-04

Abstract excerpt

In several neurodegenerative diseases including Alzheimer’s disease (AD), tau, a microtubule-associated protein (MAP) enriched in the axon, becomes hyperphosphorylated, detaches from microtubules, redistributes to the somato-dendritic compartment and self-aggregates. The mechanisms leading to neuronal dysfunction and death by tau pathology remain to be fully elucidated. C. elegans has been successfully used by se...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1caf8b25-8335-5b0f-89e6-3fc8e4b271a3
DOI
10.1101/2023.07.04.547705
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Mimicking of tau hyperphosphorylation in GABAergic motoneurons of <i>C. elegans</i> induces severe peripheral and neuronal alterationsDOI 10.1101/2023.07.04.547705
Suppression of Tau Phosphorylation Induces Neurotoxicity, Causing Developmental Defects and Degeneration in C. elegans.Semantic proximity
Dominant α-tubulin mutations rescue tauopathy neurodegenerative phenotypes in <i>C. elegans</i>Semantic proximity
Protein with tau-like repeats regulates neuronal integrity and lifespan in<i>C. elegans</i>Semantic proximity
Human tau compromises neuronal structural integrity in <i>C. elegans</i> promoted by age, stress and phosphorylationSemantic proximity
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.Semantic proximity
Caenorhabditis elegans models of tauopathySemantic proximity
Tunable Tau Expression in <i>C. elegans</i> Neurons Reveals that Early-AD Tau Phosphorylation Selectively Impacts Behavior and Mitochondrial Quality ControlSemantic proximity
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of TauopathySemantic proximity
Tau Clearance Reverses Neuronal Dysfunction in Both Young and Aged <i>C. elegans</i>Semantic proximity
A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tauSemantic proximity
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity.Semantic proximity
Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathySemantic proximity
Select a neighboring publication to make it the new centre.