Article

Glucose promotes neuron morphology abnormalities and egg-laying defects dependent of the serotonin signaling pathway in Caenorhabditis elegans

2025-09-21

Abstract excerpt

<h4>ABSTRACT</h4> A chronic hyperglycemic state can lead to neuropathological complications such as permanent nerve damage. Neuropathology is a debilitating ailment that affects nearly half of the individuals with diabetes, underscoring the relevance to investigate the impact of diet and glucose levels on the nervous system. Using the genetic model system Caenorhabditis elegans , we determined that a diet rich i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4779413-03f9-5dff-91cb-5b2095ecf930
DOI: 10.1101/2025.09.20.677429

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glucose promotes neuron morphology abnormalities and egg-laying defects dependent of the serotonin signaling pathway in Caenorhabditis elegansDOI 10.1101/2025.09.20.677429Read

Glucose availability impacts proteotoxic stress in Caenorhabditis elegansSemantic proximity Read

Glucose facilitates Aβ oligomerization and tau phosphorylation in C. elegans model of Alzheimer’s diseaseSemantic proximity Read

Bacterially produced metabolites protect C. elegans neurons from degeneration.Semantic proximity Read

Glucose Induces Sensitivity to Oxygen Deprivation and Modulates Insulin/IGF-1 Signaling and Lipid Biosynthesis inCaenorhabditis elegansSemantic proximity Read

Caenorhabditis elegans as a model for obesity research.Semantic proximity Read

High-glucose diets have sex-specific effects on aging in C. elegans: toxic to hermaphrodites but beneficial to malesSemantic proximity Read

Neuronal aging: learning from C. elegansSemantic proximity Read

Glucose enrichment accelerates C. elegans reproductive aging via non-autonomous DAF-2/insulin-like receptor signaling in somatic tissuesSemantic proximity Read

A D-2-Hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans developmentSemantic proximity Read

Fasting prevents hypoxia-induced defects of proteostasis in C. elegansSemantic proximity Read

Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegansSemantic proximity Read

Effect of altered production and storage of dopamine on development and behavior in C. elegansSemantic proximity Read

Glucose promotes neuron morphology abnormalities and egg-laying defects dependent of the serotonin signaling pathway in <i>Caenorhabditis elegans</i>

Abstract excerpt

Topics

Identifiers and source

Related research