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Article

Protein with tau-like repeats regulates neuronal integrity and lifespan in<i>C. elegans</i>

1 Jan 2013

Abstract excerpt

Protein with tau-like repeats (PTL-1) is the sole Caenorhabditis elegans homolog of tau and MAP2, which are members of the mammalian family of microtubule-associated proteins (MAPs). In mammalian neurons, tau and MAP2 are segregated, with tau being mainly localised to the axon and MAP2 mainly to the dendrite. In particular, tau plays a crucial role in pathology, as elevated levels lead to the formation of tau...

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PMID: 23525010
DOI: 10.1242/jcs.jcs124404

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