Article

Glucose availability impacts proteotoxic stress in <i>Caenorhabditis elegans</i>

2019-09-09

Abstract excerpt

Alterations in protein folding may lead to aggregation of misfolded proteins, which is strongly correlated with neurotoxicity and cell death. Protein aggregation has been shown as a normal consequence of aging, but it is largely associated with age-related disease, particularly neurodegenerative diseases like Huntington disease (HD). Huntington disease is caused by a CAG repeat expansion in the huntingtin gene an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c9d82b6-6bb7-5aa1-9d3f-e86bc7a21213
DOI: 10.1101/763060

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glucose availability impacts proteotoxic stress in <i>Caenorhabditis elegans</i>DOI 10.1101/763060Read

Glucose promotes neuron morphology abnormalities and egg-laying defects dependent of the serotonin signaling pathway in <i>Caenorhabditis elegans</i>Semantic proximity Read

Fasting prevents hypoxia-induced defects of proteostasis in <i>C. elegans</i>Semantic proximity Read

Glucose facilitates Aβ oligomerization and tau phosphorylation in <i>C. elegans</i> model of Alzheimer’s diseaseSemantic proximity Read

PRO-FitS: a novel phenotypic assay to identify enhancers of proteostasis in <i>C. elegans</i>Semantic proximity Read

A D-2-Hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in <i>Caenorhabditis elegans</i> developmentSemantic proximity Read

Fragile lifespan expansion by dietary mitohormesis in C. elegans.Semantic proximity Read

High-glucose diets have sex-specific effects on aging in C. elegans: toxic to hermaphrodites but beneficial to malesSemantic proximity Read

Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid betaSemantic proximity Read

Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.Semantic proximity Read

Proteasomal Regulation of the Hypoxic Response Modulates Aging in <i>C. elegans</i>Semantic proximity Read

Dihydrolipoamide dehydrogenase suppression induce human tau phosphorylation by increasing whole body glucose levels in a <i>C</i> . <i>elegans</i> model of Alzheimer’s DiseaseSemantic proximity Read

Islet amyloid polypeptide tagged with green fluorescent protein localises to mitochondria and forms filamentous aggregates in <i>Caenorhabditis elegans</i>Semantic proximity Read