Article

A double-assurance mechanism restrains generation of high potential transit-amplifying progenitors during neurogenesis

2025-09-17

Abstract excerpt

Stem cells can generate differentiated progeny directly or indirectly through transit-amplifying progenitors (TAPs), which are vulnerable to tumorigenic transformation. Despite clinical relevance, how stem cells regulate TAP production is unclear. Drosophila brains contain Asense+ stem cells (Type1 neuroblasts; T1NBs) that generate low neurogenic potential TAPs and Asense- stem cells (Type2 neuroblasts; T2NBs) tha...

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Literature Corpus work: 61d922af-dda1-5ff9-9c83-56c946102072
DOI: 10.1101/2025.09.16.676671

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