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Article

Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis.

Nature communications - 22 Dec 2015

Zhai Zongzhao, Kondo Shu, Ha Nati, Boquete Jean-Philippe, Brunner Michael, Ueda Ryu, Lemaitre Bruno

Abstract excerpt

Stem cell self-renewal and differentiation are coordinated to maintain tissue homeostasis and prevent cancer. Mutations causing stem cell proliferation are traditionally the focus of cancer studies. However, the contribution of the differentiating stem cell progenies in tumorigenesis is poorly characterized. Here we report that loss of the SOX transcription factor, Sox21a, blocks the differentiation programme of...

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Identifiers

PMID: 26690827
DOI: 10.1038/ncomms10219
PMCID: PMC4703904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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