Article
bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation.
Development (Cambridge, England) - 1 Apr 2012
Zacharioudaki Evanthia, Magadi Srivathsa S, Delidakis Christos
Abstract excerpt
Drosophila larval neurogenesis is an excellent system for studying the balance between self-renewal and differentiation of a somatic stem cell (neuroblast). Neuroblasts (NBs) give rise to differentiated neurons and glia via intermediate precursors called GMCs or INPs. We show that E(spl)mγ, E(spl)mβ, E(spl)m8 and Deadpan (Dpn), members of the basic helix-loop-helix-Orange protein family, are expressed in NBs but...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.