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Article

Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes.

eLife - 26 Nov 2020

Rives-Quinto Noemi, Komori Hideyuki, Ostgaard Cyrina M, Janssens Derek H, Kondo Shu, Dai Qi, Moore Adrian W, Lee Cheng-Yu

Abstract excerpt

Stem cells that indirectly generate differentiated cells through intermediate progenitors drives vertebrate brain evolution. Due to a lack of lineage information, how stem cell functionality, including the competency to generate intermediate progenitors, becomes extinguished during progenitor commitment remains unclear. Type II neuroblasts in fly larval brains divide asymmetrically to generate a neuroblast and a...

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Identifiers

PMID: 33241994
DOI: 10.7554/eLife.56187
PMCID: PMC7728440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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